MGP Database

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MGP005435

UniProt Annotations

Entry Information
Gene Namesphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
Protein EntryNSMA2_HUMAN
UniProt IDQ9NY59
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NY59-1; Sequence=Displayed; Name=2; IsoId=Q9NY59-2; Sequence=VSP_054334; Note=No experimental confirmation available.;
Biophysicochemical PropertiespH dependence: Optimum pH is 7.5.;
Catalytic ActivitySphingomyelin + H(2)O = N-acylsphingosine + phosphocholine.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:10823942, ECO:0000269|PubMed:15051724};
Developmental StageUp-regulated during G0/G1 phases.
Enzyme RegulationActivated by unsaturated fatty acids and phosphatidylserine. {ECO:0000269|PubMed:10823942}.
FunctionCatalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization. {ECO:0000269|PubMed:10823942, ECO:0000269|PubMed:14741383, ECO:0000269|PubMed:15051724}.
PathwayLipid metabolism; sphingolipid metabolism.
PtmPalmitoylated, palmitoylation-deficient proteins are targeted for lysosomal degradation. {ECO:0000250}.
SimilarityBelongs to the neutral sphingomyelinase family. {ECO:0000305}.
Subcellular LocationGolgi apparatus membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Note=May localize to detergent-resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons. According to PubMed:15051724, it localizes to plasma membrane in confluent contact-inhibited cells.
Tissue SpecificityPredominantly expressed in brain. {ECO:0000269|PubMed:10823942}.
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