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MGP005437

UniProt Annotations

Entry Information
Gene Nametripartite motif containing 36
Protein EntryTRI36_HUMAN
UniProt IDQ9NQ86
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9NQ86-1; Sequence=Displayed; Name=2; IsoId=Q9NQ86-2; Sequence=VSP_043511, VSP_043512; Note=No experimental confirmation available.; Name=3; IsoId=Q9NQ86-3; Sequence=VSP_045791, VSP_045792; Note=No experimental confirmation available.; Name=4; IsoId=Q9NQ86-4; Sequence=VSP_053818; Note=No experimental confirmation available.;
FunctionE3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization (By similarity). {ECO:0000250}.
SimilarityBelongs to the TRIM/RBCC family. {ECO:0000305}.
SimilarityContains 1 B30.2/SPRY domain. {ECO:0000255|PROSITE- ProRule:PRU00548}.
SimilarityContains 1 COS domain. {ECO:0000255|PROSITE- ProRule:PRU00586}.
SimilarityContains 1 fibronectin type-III domain. {ECO:0000255|PROSITE-ProRule:PRU00316}.
SimilarityContains 1 RING-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00175}.
SimilarityContains 2 B box-type zinc fingers. {ECO:0000255|PROSITE-ProRule:PRU00024}.
Subcellular LocationCytoplasm {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Found in the acrosomal region of elongated spermatids and mature sperm. {ECO:0000250}.
SubunitInteracts with CENPH. {ECO:0000250}.
Tissue SpecificityHighly expressed in testis, prostate and brain. Weakly expressed in kidney, lung and heart. {ECO:0000269|PubMed:15145053}.
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