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MGP005443

UniProt Annotations

Entry Information
Gene Namestabilin 2
Protein EntrySTAB2_HUMAN
UniProt IDQ8WWQ8
SpeciesHuman
Comments
Comment typeDescription
DomainRecognizes phosphatidyl serine via its epidermal growth factor-like domains.
FunctionPhosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS. {ECO:0000269|PubMed:12077138, ECO:0000269|PubMed:12473645, ECO:0000269|PubMed:15208308, ECO:0000269|PubMed:15572036, ECO:0000269|PubMed:17145755, ECO:0000269|PubMed:17675564, ECO:0000269|PubMed:17962816, ECO:0000269|PubMed:18230608, ECO:0000269|PubMed:18434317, ECO:0000269|PubMed:18573870, ECO:0000269|PubMed:19359419}.
InteractionP20065:Tmsb4x (xeno); NbExp=3; IntAct=EBI-7945957, EBI-7946048;
PtmGlycosylated. {ECO:0000269|PubMed:17145755, ECO:0000269|PubMed:19159218}.
PtmProteolytically processed to yield a 190 kDa protein. {ECO:0000269|PubMed:12626425}.
Sequence CautionSequence=AAF82398.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD18723.1; Type=Frameshift; Positions=240, 253, 588, 1586; Evidence={ECO:0000305};
SimilarityContains 17 EGF-like domains. {ECO:0000255|PROSITE- ProRule:PRU00076}.
SimilarityContains 1 Link domain. {ECO:0000255|PROSITE- ProRule:PRU00323}.
SimilarityContains 2 laminin EGF-like domains. {ECO:0000255}.
SimilarityContains 7 FAS1 domains. {ECO:0000255|PROSITE- ProRule:PRU00082}.
Subcellular LocationCell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Only a small amount appears to be present at the cell surface.
SubunitInteracts with GULP1 and heparin. Also interacts with alpha-M/beta-2 integrin (ITGAM and ITGB2) and thymosin beta 4 (TMSB4X and/or TMSB4Y). {ECO:0000269|PubMed:17675564, ECO:0000269|PubMed:18230608, ECO:0000269|PubMed:18519035}.
Tissue SpecificityHighly expressed in sinusoidal endothelial cells of liver, spleen and lymph nodes. Also expressed in non SEC- cells such as HMDMs (monocyte-derivedmacrophages), HAMs (T-cell leukemia virus type 1-associated myelopathy), and several macrophage cell line. {ECO:0000269|PubMed:11829752, ECO:0000269|PubMed:12077138, ECO:0000269|PubMed:12473645, ECO:0000269|PubMed:12626425, ECO:0000269|PubMed:17675564, ECO:0000269|PubMed:17962816}.
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