MGP Database

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MGP005447

UniProt Annotations

Entry Information
Gene Nameubiquitin-conjugating enzyme E2Q family member 1
Protein EntryUB2Q1_HUMAN
UniProt IDQ7Z7E8
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7Z7E8-1; Sequence=Displayed; Name=2; IsoId=Q7Z7E8-2; Sequence=VSP_017296;
Catalytic ActivityATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. {ECO:0000255|PROSITE- ProRule:PRU00388}.
FunctionCatalyzes the covalent attachment of ubiquitin to other proteins (Potential). May be involved in hormonal homeostasis in females (By similarity). Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation (By similarity). {ECO:0000250|UniProtKB:Q7TSS2, ECO:0000255|PROSITE- ProRule:PRU00388}.
InteractionQ9UNE7:STUB1; NbExp=3; IntAct=EBI-1783287, EBI-357085;
PathwayProtein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}.
Sequence CautionSequence=AAF71141.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH61583.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH87836.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI07058.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71173.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB65097.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the ubiquitin-conjugating enzyme family. {ECO:0000255|PROSITE-ProRule:PRU00388}.
Subcellular LocationNucleus {ECO:0000250|UniProtKB:Q7TSS2}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q7TSS2}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q7TSS2}.
SubunitMonomer and homodimer. Only the homodimer is linked to ubiquitin through thiolester activation. Interacts (via N- terminus) with B4GALT1 (via N-terminal cytoplasmic domain). The interaction is direct. {ECO:0000250|UniProtKB:Q7TSS2}.
Tissue SpecificityWidely expressed. {ECO:0000269|PubMed:11230159}.
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