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MGP005448

UniProt Annotations

Entry Information
Gene Namemyo-inositol oxygenase
Protein EntryMIOX_HUMAN
UniProt IDQ9UGB7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UGB7-1; Sequence=Displayed; Name=2; IsoId=Q9UGB7-2; Sequence=VSP_041667, VSP_041668;
Catalytic ActivityMyo-inositol + O(2) = D-glucuronate + H(2)O. {ECO:0000269|PubMed:18364358}.
CofactorName=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000269|PubMed:18364358}; Note=Binds 2 iron ions per subunit. {ECO:0000269|PubMed:18364358};
PathwayPolyol metabolism; myo-inositol degradation into D- glucuronate; D-glucuronate from myo-inositol: step 1/1.
SimilarityBelongs to the myo-inositol oxygenase family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}.
Tissue SpecificityKidney specific.
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