MGP Database

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MGP005451

UniProt Annotations

Entry Information
Gene Nameleucine rich repeat containing 16A
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q5VZK9-1; Sequence=Displayed; Name=2; IsoId=Q5VZK9-2; Sequence=VSP_032420; Note=No experimental confirmation available.; Name=3; IsoId=Q5VZK9-3; Sequence=VSP_032418, VSP_032419; Note=No experimental confirmation available.; Name=4; IsoId=Q5VZK9-4; Sequence=VSP_032415, VSP_032416, VSP_032417; Note=No experimental confirmation available.;
FunctionBinds CAPZA2 with high affinity and significantly decreases CAPZA2 affinity for actin barbed ends. Increases the rate of elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. Rapidly uncaps barbed ends capped by CAPZA2 and enhances barbed-end actin polymerization (By similarity). May control actin dynamics in lamellipodia. Required for cell migration. {ECO:0000250, ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}.
Sequence CautionSequence=BAA90912.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the CARMIL family. {ECO:0000305}.
SimilarityContains 11 LRR (leucine-rich) repeats. {ECO:0000305}.
Subcellular LocationCell projection, lamellipodium {ECO:0000269|PubMed:19846667}. Cytoplasm {ECO:0000269|PubMed:19846667}. Note=Colocalized with F-actin in lamellipodia but not with F-actin in stress fibers. Also found on macropinosomes.
SubunitInteracts via its C-terminus with CAPZA2 in cytoplasm; interaction is essential for lamellipodial protrusion and cell translocation (By similarity). Homodimer. {ECO:0000250, ECO:0000269|PubMed:19846667}.
Tissue SpecificityExpressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney. {ECO:0000269|PubMed:16054028}.
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