MGP Database

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MGP005454

UniProt Annotations

Entry Information
Gene Namesphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
Protein EntryNSMA3_HUMAN
UniProt IDQ9NXE4
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=10; Name=1; IsoId=Q9NXE4-1; Sequence=Displayed; Name=2; IsoId=Q9NXE4-2; Sequence=VSP_022481; Name=3; IsoId=Q9NXE4-3; Sequence=VSP_022480; Note=No experimental confirmation available.; Name=4; IsoId=Q9NXE4-4; Sequence=VSP_022482; Note=No experimental confirmation available.; Name=5; IsoId=Q9NXE4-5; Sequence=VSP_022479, VSP_022483; Note=No experimental confirmation available.; Name=6; IsoId=Q9NXE4-6; Sequence=VSP_044494, VSP_044495, VSP_022481; Name=7; IsoId=Q9NXE4-7; Sequence=VSP_054382, VSP_054385; Note=No experimental confirmation available.; Name=8; IsoId=Q9NXE4-8; Sequence=VSP_044494, VSP_044495, VSP_054386, VSP_022481; Note=No experimental confirmation available.; Name=9; IsoId=Q9NXE4-9; Sequence=VSP_054383, VSP_054384; Note=No experimental confirmation available.; Name=10; IsoId=Q9NXE4-10; Sequence=VSP_055343, VSP_022481; Note=No experimental confirmation available.;
Biophysicochemical PropertiespH dependence: Optimum pH is 7.0. {ECO:0000269|PubMed:16517606};
Catalytic ActivitySphingomyelin + H(2)O = N-acylsphingosine + phosphocholine.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:16517606};
Enzyme RegulationActivated by phosphatidylserine and tumor necrosis factor (TNF). Inhibited by scyphostatin. {ECO:0000269|PubMed:16517606}.
FunctionCatalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. {ECO:0000269|PubMed:16517606}.
Sequence CautionSequence=BAA91368.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91567.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92656.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:16517606}; Single-pass membrane protein {ECO:0000269|PubMed:16517606}. Golgi apparatus membrane {ECO:0000269|PubMed:16517606}; Single-pass membrane protein {ECO:0000269|PubMed:16517606}.
Tissue SpecificityWidely expressed, with highest levels in heart and skeletal muscle. {ECO:0000269|PubMed:16517606}.
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