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MGP005465

Record overview

MGPD IDMGP005465
Gene ID55679
SpeciesHomo sapiens (Human)
Gene NameLIM and senescent cell antigen-like domains 2
Gene Symbol LIMS2
SynonymsPINCH2; PINCH-2;
Alternate namesLIM and senescent cell antigen-like-containing domain protein 2; ILK-binding protein; LIM-like protein 2; particularly interesting new Cys-His protein 2;
Chromosome2
Map Location2q14.3
SummaryThis gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
OrthologsView orthologs and multiple alignments for LIMS2

Proteins

LIM and senescent cell antigen-like-containing domain protein 2 isoform 1
Refseq ID:NP_001129509
Protein GI:238859658
UniProt ID:Q7Z4I7
mRNA ID:NM_001136037
Length:363
RefSeq Status:
MTGRKRKWGETGTGSGAAPAAALRWSNMSDALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGS
CGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEAR
ELKGELYCLPCHDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEGDVVSALNKAWCV
SCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEKFPLELKKRLKKLSELTSRKAQPKATDLNSA
 
LIM and senescent cell antigen-like-containing domain protein 2 isoform 2
Refseq ID:NP_060450
Protein GI:40804748
UniProt ID:Q7Z4I7
mRNA ID:NM_017980
Length:365
RefSeq Status:
MAARLGALAASGLYRRRQHRQSPPPATGNMSDALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCC
GSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAE
ARELKGELYCLPCHDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEGDVVSALNKAW
CVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEKFPLELKKRLKKLSELTSRKAQPKATDLNSA
 
LIM and senescent cell antigen-like-containing domain protein 2 isoform 3
Refseq ID:NP_001154875
Protein GI:238776786
UniProt ID:Q7Z4I7
mRNA ID:NM_001161403
Length:341
RefSeq Status:
MTGSNMSDALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFIIGRVIKAMNNNWHPGCF
RCELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEARELKGELYCLPCHDKMGVPICGA
CRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFD
MKPVCKRCYEKFPLELKKRLKKLSELTSRKAQPKATDLNSA
 
LIM and senescent cell antigen-like-containing domain protein 2 isoform 4
Refseq ID:NP_001243471
Protein GI:374858060
UniProt ID:Q7Z4I7
mRNA ID:NM_001256542
Length:189
RefSeq Status:
MFRSDAYHPDHFNCTHCGKELTAEARELKGELYCLPCHDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQL
FGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEKFPLELKKRLKKLSELTSRKAQPKATDLNSA
 
LIM and senescent cell antigen-like-containing domain protein 2 isoform 5
Refseq ID:NP_001154876
Protein GI:238776788
UniProt ID:Q7Z4I7
mRNA ID:NM_001161404
Length:336
RefSeq Status:
MSDALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELC
DVELADLGFVKNAGRHLCRPCHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEARELKGELYCLPCHDKMGVPICGACRRPI
EGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVC
KRCYEKFPLELKKRLKKLSELTSRKAQPKATDLNSA
 
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