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MGP005473

Record overview

MGPD IDMGP005473
Gene ID55711
SpeciesHomo sapiens (Human)
Gene Namefatty acyl CoA reductase 2
Gene Symbol FAR2
SynonymsMLSTD1; SDR10E2;
Alternate namesfatty acyl-CoA reductase 2; male sterility domain-containing protein 1; short chain dehydrogenase/reductase family 10E, member 2;
Chromosome12
Map Location12p11.22
SummaryThis gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012]
OrthologsView orthologs and multiple alignments for FAR2

Proteins

fatty acyl-CoA reductase 2 isoform 1
Refseq ID:NP_060569
Protein GI:31542658
UniProt ID:Q96K12
mRNA ID:NM_018099
Length:515
RefSeq Status:
MSTIAAFYGGKSILITGATGFLGKVLMEKLFRTSPDLKVIYILVRPKAGQTLQQRVFQILDSKLFEKVKEVCPNVHEKIRAIYADLNQNDFAISKEDMQE
LLSCTNIIFHCAATVRFDDTLRHAVQLNVTATRQLLLMASQMPKLEAFIHISTAYSNCNLKHIDEVIYPCPVEPKKIIDSLEWLDDAIIDEITPKLIRDW
PNIYTYTKALGEMVVQQESRNLNIAIIRPSIVGATWQEPFPGWVDNINGPNGIIIATGKGFLRAIKATPMAVADVIPVDTVVNLMLAVGWYTAVHRPKST
LVYHITSGNMNPCNWHKMGVQVLATFEKIPFERPFRRPNANFTSNSFTSQYWNAVSHRAPAIIYDCYLRLTGRKPRMTKLMNRLLRTVSMLEYFINRSWE
WSTYNTEMLMSELSPEDQRVFNFDVRQLNWLEYIENYVLGVKKYLLKEDMAGIPKAKQRLKRLRNIHYLFNTALFLIAWRLLIARSQMARNVWFFIVSFC
YKFLSYFRASSTLKV
 
fatty acyl-CoA reductase 2 isoform 1
Refseq ID:NP_001258712
Protein GI:422398861
UniProt ID:Q96K12
mRNA ID:NM_001271783
Length:515
RefSeq Status:
Protein sequence is identical to GI:31542658 (mRNA isoform)
 
fatty acyl-CoA reductase 2 isoform 2
Refseq ID:NP_001258713
Protein GI:422398866
UniProt ID:Q9NUX8
mRNA ID:NM_001271784
Length:418
RefSeq Status:
MQELLSCTNIIFHCAATVRFDDTLRHAVQLNVTATRQLLLMASQMPKLEAFIHISTAYSNCNLKHIDEVIYPCPVEPKKIIDSLEWLDDAIIDEITPKLI
RDWPNIYTYTKALGEMVVQQESRNLNIAIIRPSIVGATWQEPFPGWVDNINGPNGIIIATGKGFLRAIKATPMAVADVIPVDTVVNLMLAVGWYTAVHRP
KSTLVYHITSGNMNPCNWHKMGVQVLATFEKIPFERPFRRPNANFTSNSFTSQYWNAVSHRAPAIIYDCYLRLTGRKPRMTKLMNRLLRTVSMLEYFINR
SWEWSTYNTEMLMSELSPEDQRVFNFDVRQLNWLEYIENYVLGVKKYLLKEDMAGIPKAKQRLKRLRNIHYLFNTALFLIAWRLLIARSQMARNVWFFIV
SFCYKFLSYFRASSTLKV
 
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