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MGP005484

UniProt Annotations

Entry Information
Gene NameCNDP dipeptidase 2 (metallopeptidase M20 family)
Protein EntryCNDP2_HUMAN
UniProt IDQ96KP4
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96KP4-1; Sequence=Displayed; Name=2; Synonyms=CPGL-B; IsoId=Q96KP4-2; Sequence=VSP_038203;
Biophysicochemical PropertiesKinetic parameters: KM=1.04 mM for Ser-Gln (at pH 7.5 and in the presence of 0.1 mM manganese ions) {ECO:0000269|PubMed:12473676, ECO:0000269|PubMed:19346245}; KM=0.6 mM for Cys-Gly (at pH 8.0 and in the presence of 50 uM manganese ions) {ECO:0000269|PubMed:12473676, ECO:0000269|PubMed:19346245}; KM=15 mM for carnosine (at pH 9.5 and in the presence of 0.1 mM manganese ions) {ECO:0000269|PubMed:12473676, ECO:0000269|PubMed:19346245};
Catalytic ActivityHydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids. {ECO:0000269|PubMed:12473676}.
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 2 manganese ions per subunit. {ECO:0000250};
Enzyme RegulationInhibited by p-hydroxymercurybenzoate. The inhibitory concentration 50% (IC(50)) is 13 uM. Inhibited by bestatin. The inhibitory concentration 50% (IC(50)) is 7 nM at pH 9.5. {ECO:0000269|PubMed:12473676}.
FunctionHydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. {ECO:0000269|PubMed:17121880, ECO:0000269|PubMed:19346245}.
InteractionQ92597:NDRG1; NbExp=1; IntAct=EBI-1190734, EBI-716486;
SimilarityBelongs to the peptidase M20A family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:12473676, ECO:0000269|PubMed:17121880}.
SubunitHomodimer. {ECO:0000269|PubMed:12473676}.
Tissue SpecificityIsoform 1 is ubiquitously expressed with higher levels in kidney and liver (at protein level). Isoform 2 is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. {ECO:0000269|PubMed:12473676, ECO:0000269|PubMed:17121880}.
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