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MGP005496

UniProt Annotations

Entry Information
Gene Namechondroitin sulfate N-acetylgalactosaminyltransferase 1
Protein EntryCGAT1_HUMAN
UniProt IDQ8TDX6
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8TDX6-1; Sequence=Displayed; Name=2; IsoId=Q8TDX6-2; Sequence=VSP_012726, VSP_012727; Note=No experimental confirmation available.; Name=3; IsoId=Q8TDX6-3; Sequence=VSP_012728; Note=No experimental confirmation available.;
Catalytic ActivityUDP-N-acetyl-D-galactosamine + beta-D- glucuronyl-(1->3)-D-galactosyl-proteoglycan = UDP + N-acetyl-D- galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D- galactosylproteoglycan.
FunctionTransfers 1,4-N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage. {ECO:0000269|PubMed:11788602, ECO:0000269|PubMed:12163485, ECO:0000269|PubMed:12446672, ECO:0000269|PubMed:17145758}.
PtmN-glycosylated. {ECO:0000269|PubMed:11788602}.
SimilarityBelongs to the chondroitin N- acetylgalactosaminyltransferase family. {ECO:0000305}.
Subcellular LocationGolgi apparatus, Golgi stack membrane {ECO:0000305|PubMed:11788602}; Single-pass type II membrane protein {ECO:0000305|PubMed:11788602}.
Tissue SpecificityUbiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined. {ECO:0000269|PubMed:11788602, ECO:0000269|PubMed:12163485, ECO:0000269|PubMed:12446672}.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_477";
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ChGn";
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