MGP Database

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MGP005497

UniProt Annotations

Entry Information
Gene Namecalcium channel, voltage-dependent, alpha 2/delta subunit 3
Protein EntryCA2D3_HUMAN
UniProt IDQ8IZS8
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8IZS8-1; Sequence=Displayed; Name=2; IsoId=Q8IZS8-2; Sequence=VSP_028064; Name=3; IsoId=Q8IZS8-3; Sequence=VSP_028064, VSP_028065, VSP_028066, VSP_028067;
DomainThe MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha- 1 (CACNA1) subunit to the plasma membrane by an integrin-like switch. {ECO:0000250}.
FunctionThe alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity). {ECO:0000250}.
MiscellaneousIn contrast to CACNA2D1 and CACNA2D2, it does not bind gabapentin, an antiepileptic drug.
PtmMay be proteolytically processed into subunits alpha-2-3 and delta-3 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role (By similarity). {ECO:0000250}.
PtmN-glycosylated. {ECO:0000250}.
SimilarityBelongs to the calcium channel subunit alpha-2/delta family. {ECO:0000305}.
SimilarityContains 1 cache domain. {ECO:0000305}.
SimilarityContains 1 VWFA domain. {ECO:0000255|PROSITE- ProRule:PRU00219}.
Subcellular LocationMembrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
SubunitDimer formed of alpha-2-2 and delta-2 chains; disulfide- linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio (By similarity). {ECO:0000250}.
Tissue SpecificityOnly detected in brain. Not present in lung, testis, aorta, spleen, jejunum, ventricular muscle and kidney (at protein level). According to PubMed:11687876, it is brain- specific, while according to PubMed:11245980, it is widely expressed. {ECO:0000269|PubMed:11687876}.
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