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MGP005502

UniProt Annotations

Entry Information
Gene Namelysine (K)-specific demethylase 3A
Protein EntryKDM3A_HUMAN
UniProt IDQ9Y4C1
SpeciesHuman
Comments
Comment typeDescription
CofactorName=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000269|PubMed:16603237}; Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000269|PubMed:16603237};
DomainLeu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors. {ECO:0000250}.
DomainThe JmjC domain and the C6-type zinc-finger are required for the demethylation activity. {ECO:0000269|PubMed:16603237}.
FunctionHistone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. {ECO:0000269|PubMed:16603237}.
Sequence CautionSequence=BAA34462.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the JHDM2 histone demethylase family. {ECO:0000305}.
SimilarityContains 1 JmjC domain. {ECO:0000255|PROSITE- ProRule:PRU00538}.
Subcellular LocationCytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Nuclear in round spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature spermatozoa (By similarity). {ECO:0000250}.
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