MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP005507

UniProt Annotations

Entry Information
Gene Nameprotein phosphatase 2, regulatory subunit B, delta
Protein Entry2ABD_HUMAN
UniProt IDQ66LE6
SpeciesHuman
Comments
Comment typeDescription
FunctionB regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55- delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). {ECO:0000250}.
Sequence CautionSequence=BAA96065.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI16703.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the phosphatase 2A regulatory subunit B family. {ECO:0000305}.
SimilarityContains 7 WD repeats. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}.
SubunitPP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with ENSA (when phosphorylated at 'Ser-67') and ARPP19 (when phosphorylated at 'Ser-62'), leading to inhibit PP2A activity (By similarity). {ECO:0000250}.
  logo