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MGP005543

Record overview

MGPD IDMGP005543
Gene ID56474
SpeciesHomo sapiens (Human)
Gene NameCTP synthase 2
Gene Symbol CTPS2
Alternate namesCTP synthase 2; CTP synthase II; CTP synthetase type 2; UTP-ammonia ligase 2; cytidine 5'-triphosphate synthetase 2;
ChromosomeX
Map LocationXp22
EC Number6.3.4.2
SummaryThe protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
OrthologsView orthologs and multiple alignments for CTPS2

Proteins

CTP synthase 2
Refseq ID:NP_001137474
Protein GI:221316689
UniProt ID:Q9NRF8
mRNA ID:NM_001144002
Length:586
RefSeq Status:
MKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDPYINIDAGTFSPYEHGEVFVLNDGGEVDLDLGNYERFLDINLYKDNNITTGKIYQHVINK
ERRGDYLGKTVQVVPHITDAVQEWVMNQAKVPVDGNKEEPQICVIELGGTIGDIEGMPFVEAFRQFQFKAKRENFCNIHVSLVPQLSATGEQKTKPTQNS
VRALRGLGLSPDLIVCRSSTPIEMAVKEKISMFCHVNPEQVICIHDVSSTYRVPVLLEEQSIVKYFKERLHLPIGDSASNLLFKWRNMADRYERLQKICS
IALVGKYTKLRDCYASVFKALEHSALAINHKLNLMYIDSIDLEKITETEDPVKFHEAWQKLCKADGILVPGGFGIRGTLGKLQAISWARTKKIPFLGVCL
GMQLAVIEFARNCLNLKDADSTEFRPNAPVPLVIDMPEHNPGNLGGTMRLGIRRTVFKTENSILRKLYGDVPFIEERHRHRFEVNPNLIKQFEQNDLSFV
GQDVDGDRMEIIELANHPYFVGVQFHPEFSSRPMKPSPPYLGLLLAATGNLNAYLQQGCKLSSSDRYSDASDDSFSEPRIAELEIS
 
CTP synthase 2
Refseq ID:NP_787055
Protein GI:28559085
UniProt ID:Q9NRF8
mRNA ID:NM_175859
Length:586
RefSeq Status:
Protein sequence is identical to GI:221316689 (mRNA isoform)
 
CTP synthase 2
Refseq ID:NP_062831
Protein GI:28559083
UniProt ID:Q9NRF8
mRNA ID:NM_019857
Length:586
RefSeq Status:
Protein sequence is identical to GI:221316689 (mRNA isoform)
 
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