MGP Database

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MGP005590

Record overview

MGPD IDMGP005590
Gene ID57038
SpeciesHomo sapiens (Human)
Gene Namearginyl-tRNA synthetase 2, mitochondrial
Gene Symbol RARS2
SynonymsPCH6; ArgRS; RARSL; DALRD2; PRO1992; dJ382I10.6;
Alternate namesprobable arginine--tRNA ligase, mitochondrial; arginine--tRNA ligase; arginine-tRNA ligase; probable arginyl-tRNA synthetase, mitochondrial;
Chromosome6
Map Location6q16.1
EC Number6.1.1.19
SummaryThe protein encoded by this gene is an arginyl-tRNA synthetase that is found in the mitochondrial matrix. Defects in this gene are a cause of pontocerebellar hypoplasia type 6 (PCH6). [provided by RefSeq, Oct 2008]
OrthologsView orthologs and multiple alignments for RARS2

Proteins

probable arginine--tRNA ligase, mitochondrial precursor
Refseq ID:NP_064716
Protein GI:197100773
UniProt ID:Q5T160
mRNA ID:NM_020320
Length:578
RefSeq Status:
MACGFRRAIACQLSRVLNLPPENLITSISAVPISQKEEVADFQLSVDSLLEKDNDHSRPDIQVQAKRLAEKLRCDTVVSEISTGQRTVNFKINRELLTKT
VLQQVIEDGSKYGLKSELFSGLPQKKIVVEFSSPNVAKKFHVGHLRSTIIGNFIANLKEALGHQVIRINYLGDWGMQFGLLGTGFQLFGYEEKLQSNPLQ
HLFEVYVQVNKEAADDKSVAKAAQEFFQRLELGDVQALSLWQKFRDLSIEEYIRVYKRLGVYFDEYSGESFYREKSQEVLKLLESKGLLLKTIKGTAVVD
LSGNGDPSSICTVMRSDGTSLYATRDLAAAIDRMDKYNFDTMIYVTDKGQKKHFQQVFQMLKIMGYDWAERCQHVPFGVVQGMKTRRGDVTFLEDVLNEI
QLRMLQNMASIKTTKELKNPQETAERVGLAALIIQDFKGLLLSDYKFSWDRVFQSRGDTGVFLQYTHARLHSLEETFGCGYLNDFNTACLQEPQSVSILQ
HLLRFDEVLYKSSQDFQPRHIVSYLLTLSHLAAVAHKTLQIKDSPPEVAGARLHLFKAVRSVLANGMKLLGITPVCRM
 
transit_peptide: 1..16
calculated_mol_wt: 1782
peptide sequence: 
MACGFRRAIACQLSRV

mat_peptide: 17..578
product: probable arginine--tRNA ligase, mitochondrial
calculated_mol_wt: 63742
peptide sequence: 
LNLPPENLITSISAVPISQKEEVADFQLSVDSLLEKDNDHSRPDIQVQAKRLAEKLRCDTVVSEISTGQRTVNFKINRELLTKTVLQQVIEDGSKYGLKS
ELFSGLPQKKIVVEFSSPNVAKKFHVGHLRSTIIGNFIANLKEALGHQVIRINYLGDWGMQFGLLGTGFQLFGYEEKLQSNPLQHLFEVYVQVNKEAADD
KSVAKAAQEFFQRLELGDVQALSLWQKFRDLSIEEYIRVYKRLGVYFDEYSGESFYREKSQEVLKLLESKGLLLKTIKGTAVVDLSGNGDPSSICTVMRS
DGTSLYATRDLAAAIDRMDKYNFDTMIYVTDKGQKKHFQQVFQMLKIMGYDWAERCQHVPFGVVQGMKTRRGDVTFLEDVLNEIQLRMLQNMASIKTTKE
LKNPQETAERVGLAALIIQDFKGLLLSDYKFSWDRVFQSRGDTGVFLQYTHARLHSLEETFGCGYLNDFNTACLQEPQSVSILQHLLRFDEVLYKSSQDF
QPRHIVSYLLTLSHLAAVAHKTLQIKDSPPEVAGARLHLFKAVRSVLANGMKLLGITPVCRM
 
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