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MGP005593

UniProt Annotations

Entry Information
Gene Nameanoctamin 2, calcium activated chloride channel
Protein EntryANO2_HUMAN
UniProt IDQ9NQ90
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NQ90-1; Sequence=Displayed; Note=Splice site between exons 4 and 5 is non-canonical.; Name=2; IsoId=Q9NQ90-2; Sequence=VSP_040493, VSP_040494; Note=Splice site between exons 4 and 5 is non-canonical.;
Enzyme RegulationChannel activity is repressed by chloride inhibitors; strongly by niflumic acid (NFA), partially by flufenamic acid (FFA), and only slightly by meclofenamic acid (MFA), 5-Nitro-2-(3-phenylpropylamino)benzoic acid (NPPB), 4- acetamido-4'-isothiocyanato-stilben-2,2'-disulfonate (SITS), and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS). {ECO:0000250}.
FunctionCalcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. {ECO:0000269|PubMed:19474308, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:21890523, ECO:0000269|PubMed:21984732}.
MiscellaneousThe term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.
Sequence CautionSequence=BAB14773.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the anoctamin family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:20056604}; Multi-pass membrane protein {ECO:0000269|PubMed:20056604}.
SubunitComponent of a presynaptic protein complex recruited to specialized plasma membrane domains of photoreceptors. Interacts with DLG4 by its C-terminal region (By similarity). {ECO:0000250}.
Tissue SpecificityRetina, especially in the photoreceptor synaptic terminals. {ECO:0000269|PubMed:19474308}.
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