MGP Database

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MGP005605

Ontology/Pathway Information

Entrez Gene ID57154
Gene NameSMAD specific E3 ubiquitin protein ligase 1
Gene Symbol SMURF1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0030424 IEA:EnsemblCaxon
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0043025 IEA:EnsemblCneuronal cell body
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IBA:GO_CentralCnucleus
GO:0005886 IDA:BHF-UCLCplasma membrane
GO:0048185 NAS:BHF-UCLFactivin binding
GO:0070411 IPI:BHF-UCLFI-SMAD binding
GO:0016874 IEA:UniProtKB-KWFligase activity
GO:0070412 IPI:BHF-UCLFR-SMAD binding
GO:0004842 IDA:UniProtKBFubiquitin-protein transferase activity
GO:0030509 IDA:UniProtKBPBMP signaling pathway
GO:0030154 IDA:UniProtKBPcell differentiation
GO:0007398 TAS:UniProtKBPectoderm development
GO:0030514 TAS:UniProtKBPnegative regulation of BMP signaling pathway
GO:0030279 IEA:EnsemblPnegative regulation of ossification
GO:0030512 IDA:BHF-UCLPnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0043161 IDA:BHF-UCLPproteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611 IDA:BHF-UCLPprotein export from nucleus
GO:0034394 IDA:BHF-UCLPprotein localization to cell surface
GO:0000209 IDA:UniProtKBPprotein polyubiquitination
GO:0016567 IDA:BHF-UCLPprotein ubiquitination
GO:0042787 IDA:UniProtKBPprotein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801 IDA:BHF-UCLPreceptor catabolic process
GO:0007179 TAS:ReactomePtransforming growth factor beta receptor signaling pathway
GO:0030579 IDA:BHF-UCLPubiquitin-dependent SMAD protein catabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_75842Antigen processing: Ubiquitination & Proteasome degradation
REACT_264478Asymmetric localization of PCP proteins
REACT_264224beta-catenin independent WNT signaling
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_116125Disease
REACT_120727Downregulation of TGF-beta receptor signaling
REACT_268718Hedgehog 'on' state
REACT_6900Immune System
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_264199PCP/CE pathway
REACT_12034Signaling by BMP
REACT_264508Signaling by Hedgehog
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_11045Signaling by Wnt
REACT_111102Signal Transduction
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_120850TGF-beta receptor signaling activates SMADs
REACT_120726TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer
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