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MGP005616

UniProt Annotations

Entry Information
Gene NameATPase, class V, type 10D
Protein EntryAT10D_HUMAN
UniProt IDQ9P241
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9P241-1; Sequence=Displayed; Name=2; IsoId=Q9P241-2; Sequence=VSP_006954; Note=No experimental confirmation available.;
Catalytic ActivityATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).
FunctionCatalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). {ECO:0000305}.
Sequence CautionSequence=BAB55221.1; Type=Frameshift; Positions=748; Evidence={ECO:0000305}; Sequence=BAC11299.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:21914794}; Multi-pass membrane protein {ECO:0000269|PubMed:21914794}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21914794}. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B.
SubunitComponent of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit. {ECO:0000305}.
Tissue SpecificityExpressed in placenta and, to a lesser extent, in kidney. {ECO:0000269|PubMed:12532265}.
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