MGP Database

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MGP005628

UniProt Annotations

Entry Information
Gene NameDown syndrome cell adhesion molecule like 1
Protein EntryDSCL1_HUMAN
UniProt IDQ8TD84
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=1a; IsoId=Q8TD84-1; Sequence=Displayed; Name=2; Synonyms=1b; IsoId=Q8TD84-2; Sequence=VSP_014978;
FunctionCell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity). {ECO:0000250}.
Sequence CautionSequence=AAM09558.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA86446.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityContains 10 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
SimilarityContains 6 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.
Subcellular LocationCell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue SpecificityDetected in heart, liver, pancreas, skeletal muscle, kidney and in brain, in particular in the amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra, thalamus and subthalamus. {ECO:0000269|PubMed:11453658, ECO:0000269|PubMed:12051741}.
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