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MGP005630

UniProt Annotations

Entry Information
Gene Namesolute carrier family 12 (potassium/chloride transporter), member 5
Protein EntryS12A5_HUMAN
UniProt IDQ9H2X9
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=KCC2a; IsoId=Q9H2X9-1; Sequence=Displayed; Name=2; Synonyms=KCC2b; IsoId=Q9H2X9-2; Sequence=VSP_029909; Note=Ref.1 (AAG43493) sequence is in conflict in position: 2:L->P. {ECO:0000305};
Enzyme RegulationInhibited by WNK3. {ECO:0000269|PubMed:21613606}.
FunctionMediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons.
MiscellaneousInhibited by furosemide and bumetanide.
SimilarityBelongs to the SLC12A transporter family. {ECO:0000305}.
Subcellular LocationMembrane; Multi-pass membrane protein.
SubunitHomomultimer and heteromultimer with other K-Cl cotransporters. Interacts with AP2A1 (By similarity). {ECO:0000250}.
Tissue SpecificityBrain specific. Detected in neuronal cells.
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