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MGP Database

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MGP005648

UniProt Annotations

Entry Information

Gene Name	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
Protein Entry	SEM6A_HUMAN
UniProt ID	Q9H2E6
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H2E6-1; Sequence=Displayed; Name=2; IsoId=Q9H2E6-2; Sequence=VSP_007113; Note=No experimental confirmation available.;
Function	Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (By similarity). {ECO:0000250}.
Sequence Caution	Sequence=BAA92606.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Belongs to the semaphorin family. {ECO:0000305}.
Similarity	Contains 1 PSI domain. {ECO:0000305}.
Similarity	Contains 1 Sema domain. {ECO:0000255\|PROSITE- ProRule:PRU00352}.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Subunit	Active as a homodimer or oligomer. The SEMA6A homodimer interacts with a PLXNA2 homodimer, giving rise to a heterotetramer (By similarity). Interacts with EVL. {ECO:0000250, ECO:0000269\|PubMed:10993894}.