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MGP005668

UniProt Annotations

Entry Information
Gene NameKIAA1598
Protein EntrySHOT1_HUMAN
UniProt IDA0MZ66
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=8; Name=1; IsoId=A0MZ66-1; Sequence=Displayed; Name=2; IsoId=A0MZ66-2; Sequence=VSP_027050, VSP_027051; Name=3; IsoId=A0MZ66-3; Sequence=VSP_027053; Note=No experimental confirmation available.; Name=4; IsoId=A0MZ66-4; Sequence=VSP_027052; Note=No experimental confirmation available.; Name=5; IsoId=A0MZ66-5; Sequence=VSP_036498; Name=6; IsoId=A0MZ66-6; Sequence=VSP_036499; Name=7; IsoId=A0MZ66-7; Sequence=VSP_036497; Name=8; IsoId=A0MZ66-8; Sequence=VSP_036498, VSP_027052;
FunctionInvolved in the generation of internal asymmetric signals required for neuronal polarization. Acts upstream of PI3K (phosphoinositide 3-kinase), by being required for spatially localized PI3K activity. Accumulates asymmetrically in a single neurite before polarization, leading to axon induction for polarization, its absence from the nascent axon's siblings by competition preventing the formation of surplus axons (By similarity). {ECO:0000250}.
Sequence CautionSequence=AAH22348.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92019.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG53052.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG53110.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the shootin family. {ECO:0000305}.
Subcellular LocationCell projection, axon {ECO:0000250}.
SubunitInteracts with RUFY3. {ECO:0000250}.
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