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MGP005679

Record overview

MGPD IDMGP005679
Gene ID57804
SpeciesHomo sapiens (Human)
Gene Namepolymerase (DNA-directed), delta 4, accessory subunit
Gene Symbol POLD4
Synonymsp12; POLDS;
Alternate namesDNA polymerase delta subunit 4; DNA polymerase delta smallest subunit p12;
Chromosome11
Map Location11q13
SummaryThis gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
OrthologsView orthologs and multiple alignments for POLD4

Proteins

DNA polymerase delta subunit 4 isoform 1
Refseq ID:NP_066996
Protein GI:258547140
UniProt ID:Q6NSD7
mRNA ID:NM_021173
Length:107
RefSeq Status:
MGRKRLITDSYPVVKRREGPAGHSKGELAPELGEEPQPRDEEEAELELLRQFDLAWQYGPCTGITRLQRWCRAKQMGLEPPPEVWQVLKTHPGDPRFQCS
LWHLYPL
 
DNA polymerase delta subunit 4 isoform 2
Refseq ID:NP_001243799
Protein GI:379056364
UniProt ID:Q9HCU8
mRNA ID:NM_001256870
Length:79
RefSeq Status:
MGRKRLITDSYPVVKRREGPAGHSKGELAPELGEEPQPRDEEEAELELLRQFDLAWQYGPCTVSGISIPYEAPRKTSCP
 
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