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MGP005689

UniProt Annotations

Entry Information
Gene Nameenolase-phosphatase 1
Protein EntryENOPH_HUMAN
UniProt IDQ9UHY7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UHY7-1; Sequence=Displayed; Name=2; IsoId=Q9UHY7-2; Sequence=VSP_021160;
Catalytic Activity5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. {ECO:0000255|HAMAP-Rule:MF_03117}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
FunctionBifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene). {ECO:0000255|HAMAP-Rule:MF_03117, ECO:0000269|PubMed:15843022}.
PathwayAmino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6. {ECO:0000255|HAMAP-Rule:MF_03117}.
PathwayAmino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6. {ECO:0000255|HAMAP-Rule:MF_03117}.
Sequence CautionSequence=AAQ13671.1; Type=Frameshift; Positions=235; Evidence={ECO:0000305};
SimilarityBelongs to the HAD-like hydrolase superfamily. MasA/MtnC family. {ECO:0000255|HAMAP-Rule:MF_03117}.
Subcellular LocationCytoplasm {ECO:0000255|HAMAP-Rule:MF_03117}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03117}.
SubunitMonomer. {ECO:0000255|HAMAP-Rule:MF_03117, ECO:0000269|PubMed:15843022}.
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