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MGP005694

UniProt Annotations

Entry Information
Gene Namejunctional adhesion molecule 2
Protein EntryJAM2_HUMAN
UniProt IDP57087
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P57087-1; Sequence=Displayed; Name=2; IsoId=P57087-2; Sequence=VSP_045153; Name=3; IsoId=P57087-3; Sequence=VSP_047352; Note=No experimental confirmation available.;
FunctionMay play a role in the processes of lymphocyte homing to secondary lymphoid organs.
InteractionQ9BX67:JAM3; NbExp=2; IntAct=EBI-3918416, EBI-4314733;
SimilarityBelongs to the immunoglobulin superfamily. {ECO:0000305}.
SimilarityContains 1 Ig-like C2-type (immunoglobulin-like) domain. {ECO:0000305}.
SimilarityContains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
Subcellular LocationCell junction, tight junction {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Localized at tight junctions of both epithelial and endothelial cells. {ECO:0000250}.
SubunitInteracts with JAM3. {ECO:0000269|PubMed:11590146}.
Tissue SpecificityHighest expression in the heart, placenta, lung, foreskin and lymph node. Prominently expressed on high endothelial venules, also present on the endothelia of other vessels. Localized to the intercellular boundaries of high endothelial cells. {ECO:0000269|PubMed:10779521}.
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