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MGP005698

UniProt Annotations

Entry Information

Gene Name	epidermal growth factor receptor pathway substrate 15-like 1
Protein Entry	EP15R_HUMAN
UniProt ID	Q9UBC2
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9UBC2-1; Sequence=Displayed; Name=2; IsoId=Q9UBC2-2; Sequence=VSP_042200; Name=3; IsoId=Q9UBC2-3; Sequence=VSP_045429; Name=4; IsoId=Q9UBC2-4; Sequence=VSP_046904, VSP_046905; Note=No experimental confirmation available.;
Caution	Studies in clathrin-mediated endocytosis used a siRNA mixture of EPS15 and EPS15L1. {ECO:0000305\|PubMed:22648170}.
Function	Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269\|PubMed:22648170, ECO:0000269\|PubMed:9407958}.
Interaction	Q969G5:PRKCDBP; NbExp=2; IntAct=EBI-2556746, EBI-3893101;
Ptm	Phosphorylated on tyrosine residues by EGFR. {ECO:0000250}.
Similarity	Contains 1 EF-hand domain. {ECO:0000255\|PROSITE- ProRule:PRU00448}.
Similarity	Contains 3 EH domains. {ECO:0000255\|PROSITE- ProRule:PRU00077}.
Subcellular Location	Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Membrane, coated pit {ECO:0000250}. Note=Localized to plasma membrane coated pits. {ECO:0000250}.
Subunit	Interacts with EPS15, AGFG1/HRB and AGFG2/HRBL. Associates with the clathrin-associated adapter protein complex 2 (AP-2) (By similarity). Interacts with FCHO1. Interacts with FCHO2. Interacts (via EH domains) with DAB2. {ECO:0000250, ECO:0000269\|PubMed:20448150, ECO:0000269\|PubMed:22484487, ECO:0000269\|PubMed:22648170}.