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MGP005719

UniProt Annotations

Entry Information
Gene Nameaminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Protein EntryADPPT_HUMAN
UniProt IDQ9NRN7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NRN7-1; Sequence=Displayed; Name=2; IsoId=Q9NRN7-2; Sequence=VSP_055783, VSP_055784; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=0.44 mM for magnesium {ECO:0000269|PubMed:18022563}; KM=0.025 mM for coenzyme A {ECO:0000269|PubMed:18022563};
Catalytic ActivityCoA-[4'-phosphopantetheine] + apo-[acyl- carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl- carrier-protein].
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:12815048, ECO:0000269|PubMed:18022563}; Note=Binds 1 Mg(2+) ion. {ECO:0000269|PubMed:12815048, ECO:0000269|PubMed:18022563};
FunctionCatalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'- phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN. {ECO:0000269|PubMed:11286508, ECO:0000269|PubMed:12815048, ECO:0000269|PubMed:18022563}.
Sequence CautionSequence=AAD34075.1; Type=Frameshift; Positions=34, 63; Evidence={ECO:0000305}; Sequence=AAF86879.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the P-Pant transferase superfamily. AcpS family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:12815048}.
SubunitMonomer. Interacts with FASN. {ECO:0000269|PubMed:12815048}.
Tissue SpecificityDetected in heart, skeletal muscle, placenta, testis, brain, pancreas, liver and kidney. {ECO:0000269|PubMed:11286508, ECO:0000269|PubMed:12815048}.
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