MGP Database

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MGP005722

UniProt Annotations

Entry Information
Gene Namepappalysin 2
Protein EntryPAPP2_HUMAN
UniProt IDQ9BXP8
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Papp-e(1); IsoId=Q9BXP8-1; Sequence=Displayed; Name=2; Synonyms=Papp-e(2); IsoId=Q9BXP8-2; Sequence=VSP_012194, VSP_012195;
Catalytic ActivityCleavage of the 143-Ser-|-Lys-144 bond in insulin-like growth factor binding protein (IGFBP)-5.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
FunctionMetalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3. {ECO:0000269|PubMed:11264294}.
Sequence CautionSequence=AAL17779.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL17780.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC11134.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the peptidase M43B family. {ECO:0000305}.
SimilarityContains 5 Sushi (CCP/SCR) domains. {ECO:0000255|PROSITE-ProRule:PRU00302}.
Subcellular LocationSecreted {ECO:0000250}.
SubunitMonomer.
Tissue SpecificityExpressed abundantly in placenta, and non- pregnant mammary gland with low expression in the kidney, fetal brain and pancreas. {ECO:0000269|PubMed:11264294, ECO:0000269|PubMed:11597188}.
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