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MGP005723

UniProt Annotations

Entry Information

Gene Name	serine racemase
Protein Entry
UniProt ID
Species	Human

Comments

Comment type	Description
Biophysicochemical Properties	Kinetic parameters: KM=6.5 mM for L-serine {ECO:0000269\|PubMed:20106978};
Catalytic Activity	D-serine = pyruvate + NH(3). {ECO:0000269\|PubMed:20106978}.
Catalytic Activity	L-serine = D-serine. {ECO:0000269\|PubMed:20106978}.
Catalytic Activity	L-serine = pyruvate + NH(3). {ECO:0000269\|PubMed:20106978}.
Cofactor	Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000269\|PubMed:20106978};
Enzyme Regulation	Allosterically activated by magnesium, and possibly also other divalent metal cations. Allosterically activated by ATP, ADP or GTP. Competitively inhibited by malonate.
Function	Catalyzes the synthesis of D-serine from L-serine. D- serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine. {ECO:0000269\|PubMed:11054547, ECO:0000269\|PubMed:20106978}.
Ptm	S-nitrosylated, leading to decrease the enzyme activity. {ECO:0000250}.
Similarity	Belongs to the serine/threonine dehydratase family. {ECO:0000305}.
Subunit	Homodimer. {ECO:0000269\|PubMed:20106978}.
Tissue Specificity	Brain: expressed at high levels in hippocampus and corpus callosum, intermediate levels in substantia nigra and caudate, and low levels in amygdala, thalamus, and subthalamic nuclei. Expressed in heart, skeletal muscle, kidney and liver. {ECO:0000269\|PubMed:15193426}.