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MGP005779

UniProt Annotations

Entry Information
Gene Namenuclear prelamin A recognition factor-like
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9H6Q4-1; Sequence=Displayed; Name=2; IsoId=Q9H6Q4-2; Sequence=VSP_025694; Name=3; IsoId=Q9H6Q4-3; Sequence=VSP_025695;
FunctionComponent of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect. {ECO:0000269|PubMed:16956324, ECO:0000269|PubMed:18270200}.
Sequence CautionSequence=AAK61251.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the NARF family. {ECO:0000305}.
SubunitComponent of the CIA complex. {ECO:0000269|PubMed:22678361, ECO:0000269|PubMed:22678362}.
Tissue SpecificityWidely expressed. {ECO:0000269|PubMed:16956324}.
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