MGP Database

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MGP005782

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group IIF
Protein EntryPA2GF_HUMAN
UniProt IDQ9BZM2
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BZM2-1; Sequence=Displayed; Name=2; IsoId=Q9BZM2-2; Sequence=VSP_037524;
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. {ECO:0000255|PROSITE- ProRule:PRU10035, ECO:0000269|PubMed:11112443}.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000269|PubMed:11112443}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000269|PubMed:11112443};
FunctionPA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference. {ECO:0000269|PubMed:11112443}.
SimilarityBelongs to the phospholipase A2 family. {ECO:0000305}.
Subcellular LocationSecreted {ECO:0000269|PubMed:11112443}.
Tissue SpecificityExpressed at high levels in placenta, testis, thymus and at lower levels in heart, kidney, liver and prostate. {ECO:0000269|PubMed:11112443}.
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