MGP Database

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MGP005788

UniProt Annotations

Entry Information
Gene Nameinositol 1,3,4,5,6-pentakisphosphate 2-kinase
Protein EntryIPPK_HUMAN
UniProt IDQ9H8X2
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=0.43 uM for Ins(1,3,4,5,6)P5 {ECO:0000269|PubMed:12084730}; KM=21 uM for ATP {ECO:0000269|PubMed:12084730}; Vmax=31 nmol/min/mg enzyme {ECO:0000269|PubMed:12084730};
Catalytic ActivityATP + 1D-myo-inositol 1,3,4,5,6- pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate. {ECO:0000269|PubMed:12084730}.
DomainThe EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
FunctionPhosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. {ECO:0000269|PubMed:12084730, ECO:0000269|PubMed:15967797}.
Sequence CautionSequence=BAB14866.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI12593.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the IPK1 type 2 family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Tissue SpecificityUbiquitously expressed, with high expression in heart, brain, testis and placenta. {ECO:0000269|PubMed:12084730}.
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