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MGP005790

UniProt Annotations

Entry Information
Gene Nameceramide kinase
Protein EntryCERK1_HUMAN
UniProt IDQ8TCT0
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TCT0-1; Sequence=Displayed; Name=2; IsoId=Q8TCT0-2; Sequence=VSP_056944; Note=No experimental confirmation available.;
Biophysicochemical PropertiespH dependence: Optimum pH is 6.0-7.5.;
Catalytic ActivityATP + ceramide = ADP + ceramide 1-phosphate.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108;
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420;
Enzyme RegulationInhibited by sulfatide. {ECO:0000269|PubMed:19168031}.
FunctionCatalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides. {ECO:0000269|PubMed:19168031}.
SimilarityContains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:19168031}. Membrane {ECO:0000269|PubMed:19168031}; Peripheral membrane protein {ECO:0000269|PubMed:19168031}.
Tissue SpecificityHigh level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung.
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