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MGP005794

Record overview

MGPD IDMGP005794
Gene ID64805
SpeciesHomo sapiens (Human)
Gene Namepurinergic receptor P2Y, G-protein coupled, 12
Gene Symbol P2RY12
SynonymsHORK3; P2Y12; ADPG-R; BDPLT8; SP1999; P2T(AC); P2Y(AC); P2Y(12)R; P2Y(ADP); P2Y(cyc);
Alternate namesP2Y purinoceptor 12; ADP-glucose receptor; G-protein coupled receptor SP1999; Gi-coupled ADP receptor HORK3; P2Y12 platelet ADP receptor; purinergic receptor P2RY12; putative G-protein coupled receptor;
Chromosome3
Map Location3q25.1
SummaryThe product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
OrthologsView orthologs and multiple alignments for P2RY12

Proteins

P2Y purinoceptor 12
Refseq ID:NP_073625
Protein GI:12232483
UniProt ID:Q9H244
mRNA ID:NM_022788
Length:342
RefSeq Status:
MQAVDNLTSAPGNTSLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGTGPLRTFVCQVT
SVIFYFTMYISISFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDKNVKKCSFLKSEFGLVWHEIVNYICQVIFWI
NFLIVIVCYTLITKELYRSYVRTRGVGKVPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLDPFIYFF
LCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM
 
P2Y purinoceptor 12
Refseq ID:NP_795345
Protein GI:29029605
UniProt ID:Q9H244
mRNA ID:NM_176876
Length:342
RefSeq Status:
Protein sequence is identical to GI:12232483 (mRNA isoform)
 
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