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MGP005799

UniProt Annotations

Entry Information
Gene Nameglucosamine-phosphate N-acetyltransferase 1
Protein EntryGNA1_HUMAN
UniProt IDQ96EK6
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=26 uM for acetyl-coenzyme A {ECO:0000269|PubMed:18601654}; KM=97 uM for glucosamine-6-phosphate {ECO:0000269|PubMed:18601654};
Catalytic ActivityAcetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate.
PathwayNucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D- glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.
SimilarityBelongs to the acetyltransferase family. GNA1 subfamily. {ECO:0000305}.
SimilarityContains 1 N-acetyltransferase domain. {ECO:0000255|PROSITE-ProRule:PRU00532}.
Subcellular LocationGolgi apparatus membrane; Peripheral membrane protein. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
SubunitHomodimer. {ECO:0000269|PubMed:18601654, ECO:0000269|PubMed:18675810}.
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