MGP Database

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MGP005802

UniProt Annotations

Entry Information
Gene Namelipin 3
Protein EntryLPIN3_HUMAN
UniProt IDQ9BQK8
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BQK8-1; Sequence=Displayed; Name=2; IsoId=Q9BQK8-2; Sequence=VSP_036885; Note=No experimental confirmation available.;
Catalytic ActivityA 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
DomainContains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif known to be essential for phosphatidate phosphatase activity. {ECO:0000250}.
DomainContains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, a motif known to be a transcriptional binding motif. {ECO:0000250}.
Enzyme RegulationInhibited by N-ethylmaleimide. {ECO:0000250}.
FunctionRegulates fatty acid metabolism. Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis (By similarity). {ECO:0000250}.
SimilarityBelongs to the lipin family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000305}.
Tissue SpecificitySignificant expression in intestine and other regions of the gastrointestinal tract. {ECO:0000269|PubMed:17158099}.
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