MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP005828

UniProt Annotations

Entry Information
Gene NameUPF3 regulator of nonsense transcripts homolog A (yeast)
Protein EntryREN3A_HUMAN
UniProt IDQ9H1J1
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; Synonyms=hUpf3p, hUPF3L; IsoId=Q9H1J1-1; Sequence=Displayed; Name=2; Synonyms=hUpf3pdelta, hUPF3S; IsoId=Q9H1J1-2; Sequence=VSP_012962; Name=3; IsoId=Q9H1J1-3; Sequence=VSP_012961; Note=No experimental confirmation available.;
FunctionInvolved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2- UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:16601204}.
InteractionQ9Y5S9:RBM8A; NbExp=4; IntAct=EBI-521530, EBI-447231; Q92900:UPF1; NbExp=4; IntAct=EBI-521530, EBI-373471;
SimilarityBelongs to the RENT3 family. {ECO:0000305}.
Subcellular LocationNucleus. Cytoplasm. Note=Shuttling between the nucleus and the cytoplasm.
SubunitFound in a post-splicing messenger ribonucleoprotein (mRNP) complex. Associates with the exon junction complex (EJC). Interacts with UPF2 and RBM8A. {ECO:0000269|PubMed:11113196, ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:11546873, ECO:0000269|PubMed:11546874}.
Tissue SpecificityIsoform 1 is strongly expressed in testis, uterus, muscle, fetal brain and spinal cord. Isoform 2 is strongly expressed in fetal brain and spinal cord. {ECO:0000269|PubMed:11113196}.
  logo