MGP Database

MGP005841

Record overview

MGPD ID	MGP005841
Gene ID	78989
Species	Homo sapiens (Human)
Gene Name	collectin sub-family member 11
Gene Symbol	COLEC11
Synonyms	3MC2; CLK1; CL-K1-I; CL-K1-II; CL-K1-IIa; CL-K1-IIb;
Alternate names	collectin-11; Collectin K1; collectin kidney protein 1;
Chromosome	2
Map Location	2p25.3
Summary	This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Orthologs	View orthologs and multiple alignments for COLEC11

Proteins

collectin-11 isoform a precursor

Refseq ID:	NP_076932
Protein GI:	13128972
UniProt ID:	Q9BWP8
mRNA ID:	NM_024027
Length:	271
RefSeq Status:

`MRGNLALVGVLISLAFLSLLPSGHPQPAGDDACSVQILVPGLKGDAGEKGDKGAPGRPGRVGPTGEKGDMGDKGQKGSVGRHGKIGPIGSKGEKGDSGDI GPPGPNGEPGLPCECSQLRKAIGEMDNQVSQLTSELKFIKNAVAGVRETESKIYLLVKEEKRYADAQLSCQGRGGTLSMPKDEAANGLMAAYLAQAGLAR VFIGINDLEKEGAFVYSDHSPMRTFNKWRSGEPNNAYDEEDCVEMVASGGWNDVACHTTMYFMCEFDKENM`

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2576
peptide sequence: 
MRGNLALVGVLISLAFLSLLPSGHP

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2576
peptide sequence: 
MRGNLALVGVLISLAFLSLLPSGHP

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2576
peptide sequence: 
MRGNLALVGVLISLAFLSLLPSGHP

sig_peptide: 1..39
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4111
peptide sequence: 
MKKQRGVGVLPALRMRGNLALVGVLISLAFLSLLPSGHP

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2576
peptide sequence: 
MRGNLALVGVLISLAFLSLLPSGHP

mat_peptide: 26..271
product: Collectin-11
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q9BWP8.1)
calculated_mol_wt: 26107
peptide sequence: 
QPAGDDACSVQILVPGLKGDAGEKGDKGAPGRPGRVGPTGEKGDMGDKGQKGSVGRHGKIGPIGSKGEKGDSGDIGPPGPNGEPGLPCECSQLRKAIGEM
DNQVSQLTSELKFIKNAVAGVRETESKIYLLVKEEKRYADAQLSCQGRGGTLSMPKDEAANGLMAAYLAQAGLARVFIGINDLEKEGAFVYSDHSPMRTF
NKWRSGEPNNAYDEEDCVEMVASGGWNDVACHTTMYFMCEFDKENM

collectin-11 isoform b

Refseq ID:	NP_954705
Protein GI:	40548420
UniProt ID:	Q9BWP8
mRNA ID:	NM_199235
Length:	268
RefSeq Status:

collectin-11 isoform c precursor
`MTPALCRSSSLASKGMRERRETKAPPDGLEESAPREKKQSQPVVTASDISKRKCTSSFVEMGSQGDMGDKGQKGSVGRHGKIGPIGSKGEKGDSGDIGPP GPNGEPGLPCECSQLRKAIGEMDNQVSQLTSELKFIKNAVAGVRETESKIYLLVKEEKRYADAQLSCQGRGGTLSMPKDEAANGLMAAYLAQAGLARVFI GINDLEKEGAFVYSDHSPMRTFNKWRSGEPNNAYDEEDCVEMVASGGWNDVACHTTMYFMCEFDKENM`

Refseq ID:	NP_001242911
Protein GI:	364502941
UniProt ID:	Q9BWP8
mRNA ID:	NM_001255982
Length:	247
RefSeq Status:

`MRGNLALVGVLISLAFLSLLPSGHPQPAGDDACSVQILVPGLKGDMGDKGQKGSVGRHGKIGPIGSKGEKGDSGDIGPPGPNGEPGLPCECSQLRKAIGE MDNQVSQLTSELKFIKNAVAGVRETESKIYLLVKEEKRYADAQLSCQGRGGTLSMPKDEAANGLMAAYLAQAGLARVFIGINDLEKEGAFVYSDHSPMRT FNKWRSGEPNNAYDEEDCVEMVASGGWNDVACHTTMYFMCEFDKENM`

collectin-11 isoform d precursor
`sig_peptide: 1..25 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2576 peptide sequence: MRGNLALVGVLISLAFLSLLPSGHP`

Refseq ID:	NP_001242912
Protein GI:	364502943
UniProt ID:	Q9BWP8
mRNA ID:	NM_001255983
Length:	247
RefSeq Status:

`MRGNLALVGVLISLAFLSLLPSGHPQPAGDDACSVQILVPGLKGDAGEKGDKGAPGRPGRVGPTGEKGEKGDSGDIGPPGPNGEPGLPCECSQLRKAIGE MDNQVSQLTSELKFIKNAVAGVRETESKIYLLVKEEKRYADAQLSCQGRGGTLSMPKDEAANGLMAAYLAQAGLARVFIGINDLEKEGAFVYSDHSPMRT FNKWRSGEPNNAYDEEDCVEMVASGGWNDVACHTTMYFMCEFDKENM`

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2576
peptide sequence: 
MRGNLALVGVLISLAFLSLLPSGHP

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2576
peptide sequence: 
MRGNLALVGVLISLAFLSLLPSGHP

collectin-11 isoform e precursor

Refseq ID:	NP_001242913
Protein GI:	364502945
UniProt ID:	Q9BWP8
mRNA ID:	NM_001255984
Length:	223
RefSeq Status:

`MRGNLALVGVLISLAFLSLLPSGHPQPAGDDACSVQILVPGLKGEKGDSGDIGPPGPNGEPGLPCECSQLRKAIGEMDNQVSQLTSELKFIKNAVAGVRE TESKIYLLVKEEKRYADAQLSCQGRGGTLSMPKDEAANGLMAAYLAQAGLARVFIGINDLEKEGAFVYSDHSPMRTFNKWRSGEPNNAYDEEDCVEMVAS GGWNDVACHTTMYFMCEFDKENM`

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2576
peptide sequence: 
MRGNLALVGVLISLAFLSLLPSGHP

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2576
peptide sequence: 
MRGNLALVGVLISLAFLSLLPSGHP

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2576
peptide sequence: 
MRGNLALVGVLISLAFLSLLPSGHP

collectin-11 isoform f precursor

Refseq ID:	NP_001242914
Protein GI:	364502949
UniProt ID:	Q9BWP8
mRNA ID:	NM_001255985
Length:	285
RefSeq Status:

`MKKQRGVGVLPALRMRGNLALVGVLISLAFLSLLPSGHPQPAGDDACSVQILVPGLKGDAGEKGDKGAPGRPGRVGPTGEKGDMGDKGQKGSVGRHGKIG PIGSKGEKGDSGDIGPPGPNGEPGLPCECSQLRKAIGEMDNQVSQLTSELKFIKNAVAGVRETESKIYLLVKEEKRYADAQLSCQGRGGTLSMPKDEAAN GLMAAYLAQAGLARVFIGINDLEKEGAFVYSDHSPMRTFNKWRSGEPNNAYDEEDCVEMVASGGWNDVACHTTMYFMCEFDKENM`

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2576
peptide sequence: 
MRGNLALVGVLISLAFLSLLPSGHP

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2576
peptide sequence: 
MRGNLALVGVLISLAFLSLLPSGHP

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2576
peptide sequence: 
MRGNLALVGVLISLAFLSLLPSGHP

sig_peptide: 1..39
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4111
peptide sequence: 
MKKQRGVGVLPALRMRGNLALVGVLISLAFLSLLPSGHP

collectin-11 isoform g

Refseq ID:	NP_001242915
Protein GI:	364502947
UniProt ID:	Q9BWP8
mRNA ID:	NM_001255986
Length:	245
RefSeq Status:

`MWWVPPSPYGCLPCALPGDAGEKGDKGAPGRPGRVGPTGEKGDMGDKGQKGSVGRHGKIGPIGSKGEKGDSGDIGPPGPNGEPGLPCECSQLRKAIGEMD NQVSQLTSELKFIKNAVAGVRETESKIYLLVKEEKRYADAQLSCQGRGGTLSMPKDEAANGLMAAYLAQAGLARVFIGINDLEKEGAFVYSDHSPMRTFN KWRSGEPNNAYDEEDCVEMVASGGWNDVACHTTMYFMCEFDKENM`

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2576
peptide sequence: 
MRGNLALVGVLISLAFLSLLPSGHP

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2576
peptide sequence: 
MRGNLALVGVLISLAFLSLLPSGHP

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2576
peptide sequence: 
MRGNLALVGVLISLAFLSLLPSGHP

sig_peptide: 1..39
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4111
peptide sequence: 
MKKQRGVGVLPALRMRGNLALVGVLISLAFLSLLPSGHP

collectin-11 isoform h

Refseq ID:	NP_001242916
Protein GI:	364502951
UniProt ID:	Q9BWP8
mRNA ID:	NM_001255987
Length:	221
RefSeq Status:

`MWWVPPSPYGCLPCALPGDMGDKGQKGSVGRHGKIGPIGSKGEKGDSGDIGPPGPNGEPGLPCECSQLRKAIGEMDNQVSQLTSELKFIKNAVAGVRETE SKIYLLVKEEKRYADAQLSCQGRGGTLSMPKDEAANGLMAAYLAQAGLARVFIGINDLEKEGAFVYSDHSPMRTFNKWRSGEPNNAYDEEDCVEMVASGG WNDVACHTTMYFMCEFDKENM`

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2576
peptide sequence: 
MRGNLALVGVLISLAFLSLLPSGHP

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2576
peptide sequence: 
MRGNLALVGVLISLAFLSLLPSGHP

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2576
peptide sequence: 
MRGNLALVGVLISLAFLSLLPSGHP

sig_peptide: 1..39
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4111
peptide sequence: 
MKKQRGVGVLPALRMRGNLALVGVLISLAFLSLLPSGHP

collectin-11 isoform i

Refseq ID:	NP_001242917
Protein GI:	364502953
UniProt ID:	Q9BWP8
mRNA ID:	NM_001255988
Length:	221
RefSeq Status:

`MWWVPPSPYGCLPCALPGDAGEKGDKGAPGRPGRVGPTGEKGEKGDSGDIGPPGPNGEPGLPCECSQLRKAIGEMDNQVSQLTSELKFIKNAVAGVRETE SKIYLLVKEEKRYADAQLSCQGRGGTLSMPKDEAANGLMAAYLAQAGLARVFIGINDLEKEGAFVYSDHSPMRTFNKWRSGEPNNAYDEEDCVEMVASGG WNDVACHTTMYFMCEFDKENM`

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2576
peptide sequence: 
MRGNLALVGVLISLAFLSLLPSGHP

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2576
peptide sequence: 
MRGNLALVGVLISLAFLSLLPSGHP

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2576
peptide sequence: 
MRGNLALVGVLISLAFLSLLPSGHP

sig_peptide: 1..39
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4111
peptide sequence: 
MKKQRGVGVLPALRMRGNLALVGVLISLAFLSLLPSGHP

collectin-11 isoform j

Refseq ID:	NP_001242918
Protein GI:	364502955
UniProt ID:	Q9BWP8
mRNA ID:	NM_001255989
Length:	197
RefSeq Status:

`MWWVPPSPYGCLPCALPGEKGDSGDIGPPGPNGEPGLPCECSQLRKAIGEMDNQVSQLTSELKFIKNAVAGVRETESKIYLLVKEEKRYADAQLSCQGRG GTLSMPKDEAANGLMAAYLAQAGLARVFIGINDLEKEGAFVYSDHSPMRTFNKWRSGEPNNAYDEEDCVEMVASGGWNDVACHTTMYFMCEFDKENM`