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MGP005844

Record overview

MGPD IDMGP005844
Gene ID79017
SpeciesHomo sapiens (Human)
Gene Namegamma-glutamylcyclotransferase
Gene Symbol GGCT
SynonymsGGC; GCTG; CRF21; C7orf24;
Alternate namesgamma-glutamylcyclotransferase; cytochrome c-releasing factor 21; gamma -glutamyl cyclotransferase;
Chromosome7
Map Location7p15-p14
EC Number2.3.2.4
SummaryThe protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
OrthologsView orthologs and multiple alignments for GGCT

Proteins

gamma-glutamylcyclotransferase isoform 1
Refseq ID:NP_076956
Protein GI:13129018
UniProt ID:O75223
mRNA ID:NM_024051
Length:188
RefSeq Status:
MANSGCKDVTGPDEESFLYFAYGSNLLTERIHLRNPSAAFFCVARLQDFKLDFGNSQGKTSQTWHGGIATIFQSPGDEVWGVVWKMNKSNLNSLDEQEGV
KSGMYVVIEVKVATQEGKEITCRSYLMTNYESAPPSPQYKKIICMGAKENGLPLEYQEKLKAIEPNDYTGKVSEEIEDIIKKGETQTL
 
gamma-glutamylcyclotransferase isoform 2
Refseq ID:NP_001186744
Protein GI:315360618
UniProt ID:O75223
mRNA ID:NM_001199815
Length:166
RefSeq Status:
MANSGCKDVTGPDEESFLYFAYGSNLLTERIHLRNPSAAFFCVARLQDFKLDFGNSQGKTSQTWHGGIATIFQSPGDEVWGVVWKMNKSNLNSLDEWRKK
RHTAFQNQGNHPCKHKTRMWDRDPKIPVQNLSLALCWQAQSGHGTCNRLFAWVQKKMVCRWSIKRS
 
gamma-glutamylcyclotransferase isoform 3
Refseq ID:NP_001186745
Protein GI:315360620
UniProt ID:O75223
mRNA ID:NM_001199816
Length:114
RefSeq Status:
MANSGCKDVTGPDEESFLYFAYGSNLLTERIHLRNPSAAFFCVARLQDFKLDFGNSQGKTSQTWHGGIATIFQSPGDEVWGVVWKMNKSNLNSLDELFAW
VQKKMVCRWSIKRS
 
gamma-glutamylcyclotransferase isoform 4
Refseq ID:NP_001186746
Protein GI:315360622
UniProt ID:O75223
mRNA ID:NM_001199817
Length:94
RefSeq Status:
MANSGCKDVTGPDEESFLYFAYGSNLLTERIHLRNPSAAFFCVARLQIICMGAKENGLPLEYQEKLKAIEPNDYTGKVSEEIEDIIKKGETQTL
 
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