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MGP005863

UniProt Annotations

Entry Information
Gene Namethiamine triphosphatase
Protein EntryTHTPA_HUMAN
UniProt IDQ9BU02
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BU02-1; Sequence=Displayed; Name=2; IsoId=Q9BU02-2; Sequence=VSP_047213, VSP_047214; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=8 uM for thiamine triphosphate {ECO:0000269|PubMed:23707715}; Vmax=59 umol/min/mg enzyme {ECO:0000269|PubMed:23707715};
Catalytic ActivityThiamine triphosphate + H(2)O = thiamine diphosphate + phosphate. {ECO:0000269|PubMed:23707715}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:23707715}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000269|PubMed:23707715};
FunctionHydrolase highly specific for thiamine triphosphate (ThTP). {ECO:0000269|PubMed:11827967, ECO:0000269|PubMed:23707715}.
SimilarityBelongs to the ThTPase family. {ECO:0000305}.
SimilarityContains 1 CYTH domain. {ECO:0000255|PROSITE- ProRule:PRU01044}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:11827967}.
SubunitMonomer. {ECO:0000269|PubMed:23707715}.
Tissue SpecificityWidely expressed but at a low level. {ECO:0000269|PubMed:11827967}.
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