MGP Database

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MGP005879

Record overview

MGPD IDMGP005879
Gene ID79577
SpeciesHomo sapiens (Human)
Gene Namecell division cycle 73
Gene Symbol CDC73
SynonymsHYX; FIHP; HPTJT; HRPT1; HRPT2; C1orf28;
Alternate namesparafibromin; Paf1/RNA polymerase II complex component; cell division cycle 73, Paf1/RNA polymerase II complex component, homolog; cell division cycle protein 73 homolog; hyperparathyroidism 2 protein;
Chromosome1
Map Location1q25
SummaryThis gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009]
OrthologsView orthologs and multiple alignments for CDC73

Proteins

parafibromin
Refseq ID:NP_078805
Protein GI:40018640
UniProt ID:Q6P1J9
mRNA ID:NM_024529
Length:531
RefSeq Status:
MADVLSVLRQYNIQKKEIVVKGDEVIFGEFSWPKNVKTNYVVWGTGKEGQPREYYTLDSILFLLNNVHLSHPVYVRRAATENIPVVRRPDRKDLLGYLNG
EASTSASIDRSAPLEIGLQRSTQVKRAADEVLAEAKKPRIEDEECVRLDKERLAARLEGHKEGIVQTEQIRSLSEAMSVEKIAAIKAKIMAKKRSTIKTD
LDDDITALKQRSFVDAEVDVTRDIVSRERVWRTRTTILQSTGKNFSKNIFAILQSVKAREEGRAPEQRPAPNAAPVDPTLRTKQPIPAAYNRYDQERFKG
KEETEGFKIDTMGTYHGMTLKSVTEGASARKTQTPAAQPVPRPVSQARPPPNQKKGSRTPIIIIPAATTSLITMLNAKDLLQDLKFVPSDEKKKQGCQRE
NETLIQRRKDQMQPGGTAISVTVPYRVVDQPLKLMPQDWDRVVAVFVQGPAWQFKGWPWLLPDGSPVDIFAKIKAFHLKYDEVRLDPNVQKWDVTVLELS
YHKRHLDRPVFLRFWETLDRYMVKHKSHLRF
 
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