MGP Database

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MGP005879

Ontology/Pathway Information

Entrez Gene ID79577
Gene Namecell division cycle 73
Gene Symbol CDC73
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0016593 IDA:UniProtKBCCdc73/Paf1 complex
GO:0005634 IDA:UniProtKBCnucleus
GO:0000993 IDA:UniProtKBFRNA polymerase II core binding
GO:0007049 IEA:UniProtKB-KWPcell cycle
GO:0071222 ISS:UniProtKBPcellular response to lipopolysaccharide
GO:0001711 ISS:UniProtKBPendodermal cell fate commitment
GO:0033523 IDA:UniProtKBPhistone H2B ubiquitination
GO:0010390 IDA:UniProtKBPhistone monoubiquitination
GO:0006378 IMP:UniProtKBPmRNA polyadenylation
GO:0008285 IDA:UniProtKBPnegative regulation of cell proliferation
GO:0050680 IMP:UniProtKBPnegative regulation of epithelial cell proliferation
GO:0048147 IMP:UniProtKBPnegative regulation of fibroblast proliferation
GO:2000134 IDA:UniProtKBPnegative regulation of G1/S transition of mitotic cell cycle
GO:0045638 IDA:UniProtKBPnegative regulation of myeloid cell differentiation
GO:0000122 IMP:UniProtKBPnegative regulation of transcription from RNA polymerase II promoter
GO:0031442 IMP:UniProtKBPpositive regulation of mRNA 3'-end processing
GO:0032968 IDA:UniProtKBPpositive regulation of transcription elongation from RNA polymerase II promoter
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0030177 IDA:UniProtKBPpositive regulation of Wnt signaling pathway
GO:0031648 IMP:UniProtKBPprotein destabilization
GO:0019827 ISS:UniProtKBPstem cell maintenance
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
GO:0016055 IEA:UniProtKB-KWPWnt signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_116125Disease
REACT_264242formation of the beta-catenin:TCF transactivating complex
REACT_268718Hedgehog 'on' state
REACT_264594misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_264378RNF mutants show enhanced WNT signaling and proliferation
REACT_264508Signaling by Hedgehog
REACT_11045Signaling by Wnt
REACT_264125Signaling by WNT in cancer
REACT_111102Signal Transduction
REACT_264596TCF dependent signaling in response to WNT
REACT_264356XAV939 inhibits tankyrase, stabilizing AXIN
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