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MGP005887

UniProt Annotations

Entry Information
Gene Namepolypeptide N-acetylgalactosaminyltransferase 14
Protein EntryGLT14_HUMAN
UniProt IDQ96FL9
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q96FL9-1; Sequence=Displayed; Note=Major isoform.; Name=2; IsoId=Q96FL9-2; Sequence=VSP_011222; Note=No experimental confirmation available.; Name=3; IsoId=Q96FL9-3; Sequence=VSP_011221; Note=Minor isoform.; Name=4; IsoId=Q96FL9-4; Sequence=VSP_045121;
Catalytic ActivityUDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide. {ECO:0000269|PubMed:12507512}.
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
DomainThere are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. {ECO:0000250}.
DomainThe ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity. {ECO:0000250}.
FunctionCatalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney.
PathwayProtein modification; protein glycosylation.
Sequence CautionSequence=BAB14795.1; Type=Miscellaneous discrepancy; Note=Chimeric at the C-terminus.; Evidence={ECO:0000305};
SimilarityBelongs to the glycosyltransferase 2 family. GalNAc-T subfamily. {ECO:0000305}.
SimilarityContains 1 ricin B-type lectin domain. {ECO:0000255|PROSITE-ProRule:PRU00174}.
Subcellular LocationGolgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Tissue SpecificityDetected in renal tubules (at protein level). Highly expressed in fetal and adult kidney. Widely expressed at low level. Weakly expressed in whole brain, cerebellum, thymus, lung, mammary gland, liver, stomach, small intestine, colon, pancreas, spleen, bladder, uterus, placenta, testis, ovary, skeletal muscle, leukocyte, B-cell, bone marrow, fetal brain, fetal thymus, fetal lung, fetal liver, fetal small intestine, fetal spleen, fetal skeletal and fetus. Detected in renal tubules (at protein level). {ECO:0000269|PubMed:12507512, ECO:0000269|PubMed:20179215}.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=Polypeptide N-acetylgalactosaminyltransferase 14; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_497";
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=GALNT14";
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