MGP Database

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MGP005903

UniProt Annotations

Entry Information
Gene Nametransducin (beta)-like 1 X-linked receptor 1
Protein EntryTBL1R_HUMAN
UniProt IDQ9BZK7
SpeciesHuman
Comments
Comment typeDescription
DomainThe F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes. {ECO:0000250}.
FunctionF-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. {ECO:0000269|PubMed:14980219}.
Sequence CautionSequence=AAH60320.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
SimilarityBelongs to the WD repeat EBI family. {ECO:0000305}.
SimilarityContains 1 F-box-like domain. {ECO:0000305}.
SimilarityContains 1 LisH domain. {ECO:0000255|PROSITE- ProRule:PRU00126}.
SimilarityContains 8 WD repeats. {ECO:0000255|PROSITE- ProRule:PRU00221}.
Subcellular LocationNucleus {ECO:0000305}.
SubunitComponent of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Probable component of some E3 ubiquitin ligase complex. Interacts with histones H2B and H4.
Tissue SpecificityUbiquitous.
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