MGP Database

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MGP005921

UniProt Annotations

Entry Information
Gene Nameagmatine ureohydrolase (agmatinase)
Protein EntrySPEB_HUMAN
UniProt IDQ9BSE5
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityAgmatine + H(2)O = putrescine + urea. {ECO:0000269|PubMed:11914032}.
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|PROSITE-ProRule:PRU00742};
PathwayAmine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from agmatine: step 1/1.
SimilarityBelongs to the arginase family. Agmatinase subfamily. {ECO:0000255|PROSITE-ProRule:PRU00742}.
Subcellular LocationMitochondrion.
Tissue SpecificityHighly expressed in liver and kidney. Also found in skeletal muscle, fetal liver, brain, testis, skin and the gastrointestinal tract. Within brain, expression is higher in the cerebral cortex with lower levels in the medulla and spinal cord. {ECO:0000269|PubMed:11804860, ECO:0000269|PubMed:11914032}.
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