MGP Database

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MGP005933

UniProt Annotations

Entry Information
Gene Namephospholipase B domain containing 1
Protein EntryPLBL1_HUMAN
UniProt IDQ6P4A8
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiespH dependence: Optimum pH is 7.4. {ECO:0000269|PubMed:19019078};
FunctionIn view of the small size of the putative binding pocket, it has been proposed that it may act as an amidase or a peptidase (By similarity). Exhibits a weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids. {ECO:0000250, ECO:0000269|PubMed:19019078}.
PtmThe maturation cleavages that produces chains A and B are required to open the putative substrate binding pocket. Both chains A and B remain associated in the mature protein. {ECO:0000269|PubMed:19019078}.
Sequence CautionSequence=AAH00909.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15442.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the phospholipase B-like family. {ECO:0000305}.
Subcellular LocationLysosome {ECO:0000250}.
SubunitMay form a homodimer, each monomer is composed of a chain A and a chain B. {ECO:0000269|PubMed:19019078}.
Tissue SpecificityExpressed in neutrophils and monocytes. {ECO:0000269|PubMed:19019078}.
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