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MGP005938

UniProt Annotations

Entry Information
Gene Namenucleoporin 85kDa
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9BW27-1; Sequence=Displayed; Name=2; IsoId=Q9BW27-2; Sequence=VSP_056080, VSP_056081, VSP_056082; Note=No experimental confirmation available.; Name=3; IsoId=Q9BW27-3; Sequence=VSP_056079; Note=No experimental confirmation available.;
FunctionEssential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP98/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2- activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl- inositol 3-kinase-Rac-lammellipodium protrusion cascade. {ECO:0000269|PubMed:12718872, ECO:0000269|PubMed:15995708, ECO:0000269|PubMed:16807356}.
InteractionA0A024R2Q0:CCR2; NbExp=3; IntAct=EBI-716392, EBI-9822346;
Sequence CautionSequence=CAD38749.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the nucleoporin Nup85 family. {ECO:0000305}.
Subcellular LocationNucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Nucleus membrane. Note=During mitosis, localizes to the kinetochores and spindle poles. Upon CCl2 stimulation translocates from the cytoplasm to the membrane and colocalizes with CCR2 at the front of migrating cells.
SubunitComponent of the nuclear pore complex (NPC). Component of the NPC Nup107-160 subcomplex, consisting of at least NUP107, NUP98/Nup96, NUP160, NUP133, NUP85, NUP37, NUP43 and SEC13. Interacts with NUP160, NUP133 and SEC13. Interacts with NUP37, NUP107 and NUP43. Interacts with CCR2. {ECO:0000269|PubMed:12196509, ECO:0000269|PubMed:12718872, ECO:0000269|PubMed:15146057, ECO:0000269|PubMed:15995708}.
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