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MGP005943

Record overview

MGPD IDMGP005943
Gene ID79947
SpeciesHomo sapiens (Human)
Gene Namedehydrodolichyl diphosphate synthase
Gene Symbol DHDDS
SynonymsDS; CIT; CPT; HDS; RP59;
Alternate namesdehydrodolichyl diphosphate syntase complex subunit DHDDS; cis-IPTase; cis-isoprenyltransferase; cis-prenyl transferase; dedol-PP synthase; epididymis tissue protein Li 189m;
Chromosome1
Map Location1p36.11
EC Number2.5.1.87
SummaryThe protein encoded by this gene catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins. Mutations in this gene are associated with retinitis pigmentosa type 59. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
OrthologsView orthologs and multiple alignments for DHDDS

Proteins

dehydrodolichyl diphosphate syntase complex subunit DHDDS isoform 1
Refseq ID:NP_995583
Protein GI:45580738
UniProt ID:Q86SQ9
mRNA ID:NM_205861
Length:333
RefSeq Status:
MSWIKEGELSLWERFCANIIKAGPMPKHIAFIMDGNRRYAKKCQVERQEGHSQGFNKLAETLRWCLNLGILEVTVYAFSIENFKRSKSEVDGLMDLARQK
FSRLMEEKEKLQKHGVCIRVLGDLHLLPLDLQELIAQAVQATKNYNKCFLNVCFAYTSRHEISNAVREMAWGVEQGLLDPSDISESLLDKCLYTNRSPHP
DILIRTSGEVRLSDFLLWQTSHSCLVFQPVLWPEYTFWNLFEAILQFQMNHSVLQKARDMYAEERKRQQLERDQATVTEQLLREGLQASGDAQLRRTRLH
KLSARREERVQGFLQALELKRADWLARLGTASA
 
dehydrodolichyl diphosphate syntase complex subunit DHDDS isoform 2
Refseq ID:NP_079163
Protein GI:45580742
UniProt ID:Q86SQ9
mRNA ID:NM_024887
Length:334
RefSeq Status:
MSWIKEGELSLWERFCANIIKAGPMPKHIAFIMDGNRRYAKKCQVERQEGHSQGFNKLAETLRWCLNLGILEVTVYAFSIENFKRSKSEVDGLMDLARQK
FSRLMEEKEKLQKHGVCIRVLGDLHLLPLDLQELIAQAVQATKNYNKCFLNVCFAYTSRHEISNAVREMAWGVEQGLLDPSDISESLLDKCLYTNRSPHP
DILIRTSGEVRLSDFLLWQTSHSCLVFQPVLWPEYTFWNLFEAILQFQMNHSVLQQKARDMYAEERKRQQLERDQATVTEQLLREGLQASGDAQLRRTRL
HKLSARREERVQGFLQALELKRADWLARLGTASA
 
dehydrodolichyl diphosphate syntase complex subunit DHDDS isoform 3
Refseq ID:NP_001230493
Protein GI:343790878
UniProt ID:Q86SQ9
mRNA ID:NM_001243564
Length:299
RefSeq Status:
MSWIKEGELSLWERFCANIIKAGPMPKHIAFIMDGNRRYAKKCQVERQEGHSQGFNKLAETLRWCLNLGILEVTVYAFSIENFKRSKSEVDGLMDLARQK
FSRLMEEKEKLQKHGVCIRVLGDLHLLPLDLQELIAQAVQATKNYNNDISESLLDKCLYTNRSPHPDILIRTSGEVRLSDFLLWQTSHSCLVFQPVLWPE
YTFWNLFEAILQFQMNHSVLQKARDMYAEERKRQQLERDQATVTEQLLREGLQASGDAQLRRTRLHKLSARREERVQGFLQALELKRADWLARLGTASA
 
dehydrodolichyl diphosphate syntase complex subunit DHDDS isoform 4
Refseq ID:NP_001230494
Protein GI:343790880
UniProt ID:Q86SQ9
mRNA ID:NM_001243565
Length:294
RefSeq Status:
MSWIKEGELSLWERFCANIIKAGPMPKHIAFIMDGNRRYAKKCQVERQEGHSQGFNKLAETLRWCLNLGILEVTVYAFSIENFKRSKSEVDGLMDLARQK
FSRLMEEKCFLNVCFAYTSRHEISNAVREMAWGVEQGLLDPSDISESLLDKCLYTNRSPHPDILIRTSGEVRLSDFLLWQTSHSCLVFQPVLWPEYTFWN
LFEAILQFQMNHSVLQKARDMYAEERKRQQLERDQATVTEQLLREGLQASGDAQLRRTRLHKLSARREERVQGFLQALELKRADWLARLGTASA
 
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