MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP005959

UniProt Annotations

Entry Information
Gene NameADAM metallopeptidase with thrombospondin type 1 motif, 20
Protein EntryATS20_HUMAN
UniProt IDP59510
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P59510-1; Sequence=Displayed; Name=2; IsoId=P59510-2; Sequence=VSP_007106, VSP_007107, VSP_007108; Name=3; IsoId=P59510-3; Sequence=VSP_047084;
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
FunctionMay play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease- independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain.
PtmGlycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)- (S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W- X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). {ECO:0000250}.
PtmThe precursor is cleaved by a furin endopeptidase. {ECO:0000250}.
SimilarityContains 15 TSP type-1 domains. {ECO:0000255|PROSITE- ProRule:PRU00210}.
SimilarityContains 1 disintegrin domain. {ECO:0000305}.
SimilarityContains 1 GON domain. {ECO:0000255|PROSITE- ProRule:PRU00383}.
SimilarityContains 1 peptidase M12B domain. {ECO:0000255|PROSITE-ProRule:PRU00276}.
Subcellular LocationSecreted, extracellular space, extracellular matrix {ECO:0000250}.
Tissue SpecificityVery sparingly expressed, although is detected at low levels in testis, prostate, ovary, heart, placenta, lung and pancreas. Overexpressed in several brain, colon and breast carcinomas.
  logo